Rosmanol
- Product Name
- Rosmanol
- CAS No.
- 80225-53-2
- Chemical Name
- Rosmanol
- Synonyms
- Rosmano;20-Deoxocarnosol;rat tail oxalic acid;rosemary antioxidant;Rosmanol,Inhibitor,inhibit;Keywords honeysuckle extract;6β,7α,11,12-Tetrahydroxyabieta-8,11,13-trien-20-oic acid 20,6-lactone;(4bR,8aS,9R,10S)-3,4,10-trihydroxy-2-isopropyl-8,8-dimethyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epoxymethano)phenanthren-12-one;(4bR,8aS,9S,10S)-3,4,10-Trihydroxy-2-isopropyl-8,8-dimethyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epoxymethano)phenanthren-12-one;(4aR,10aα)-1,3,4,9,10,10a-Hexahydro-5,6,9α-trihydroxy-1,1-dimethyl-7-(1-methylethyl)-2H-10β,4aβ-(epoxymethano)phenanthren-12-one
- CBNumber
- CB82131157
- Molecular Formula
- C20H26O5
- Formula Weight
- 346.42
- MOL File
- 80225-53-2.mol
Rosmanol Property
- Melting point:
- 212-213 °C(Solv: ethyl ether (60-29-7))
- Boiling point:
- 574.2±50.0 °C(Predicted)
- Density
- 1.33
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble
- form
- A solid
- pka
- 9.07±0.60(Predicted)
N-Bromosuccinimide Price
- Product number
- R2999-90
- Product name
- Rosmarinic Acid
- Packaging
- 50mg
- Price
- $276
- Updated
- 2021/12/16
- Product number
- 300896
- Product name
- Rosmarinic acid
- Packaging
- 20mg
- Price
- $277
- Updated
- 2021/12/16
- Product number
- 020735
- Product name
- Rosmarinic Acid
- Packaging
- 5g
- Price
- $496
- Updated
- 2021/12/16
- Product number
- 256499
- Product name
- Rosmarinic acid
- Packaging
- 50mg
- Price
- $403
- Updated
- 2021/12/16
- Product number
- CS-0032078
- Product name
- Rosmanol
- Purity
- 97.02%
- Packaging
- 10mg
- Price
- $280
- Updated
- 2021/12/16
Rosmanol Chemical Properties,Usage,Production
Anticancer Research
This is a polyphenol and an ester of caffeic acid and 3,4-dihydroxyphylllique acid.This is commonly found in Boraginaceae species and Nepettoideae, a Lamiaceaesubfamily. It plays an important role in anti-inflammatory, antitumor, andantiproliferation activities. It shows a dose-dependent inhibition of invasion,migration, and adhesion of LS-174-T human colon carcinoma cells. It inhibits thebone metastasis from breast cancer via NF-κB and its downward IL-8 pathway(Wang et al. 2012). It reduces ERK and COX-2 phosphorylation in colon carcinoma.It reduces the activity of DNA methyltransferase and interferes with RANKL/RANK/OPG networks in breast cancer cells. It targets NF-kB pathway in U938cells and PKA/CREB/MITF pathways in melanoma cells (Singh et al. 2016b). InU938 human leukemic cells, it sensitizes TNF-α-induced apoptosis by affectingNF-kB and ROS and inhibits the activation of NF-kB by inhibiting IκBαphosphorylation and degradation. It also reduces the levels of promoter activity ofCOX-2 protein induced by TPA in HT-29 colon cancer cells and antagonizes TPAstimulating effects on COX-2 expression (Petersen and Simmonds 2003).
Cytotoxicity
IC50 (μg/mL): 1.71 (A2780), 6.96(SW1573), 10.13 (WiDr), 10.13 (T-47D),1.46 (HBL-100) (Guerrero et al. 2006;Zhang et al. 2017)
Rosmanol Preparation Products And Raw materials
Raw materials
Preparation Products
Rosmanol Suppliers
View Lastest Price from Rosmanol manufacturers
- Product
- Rosmanol 80225-53-2
- Price
- US $8.00/KG
- Min. Order
- 1g
- Purity
- ＞98% HPLC
- Supply Ability
- kg--ton
- Release date
- 2020-02-20